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A general one-pot, solvent-free solid-state synthesis of biocompatible metal nanoparticles using dextran as a tool: Evaluation of their catalytic and anti-cancer activities

Authors
Song, S.G.[Song, Sun Gu]Oh, C.[Oh, Changsuk]Yoo, S.[Yoo, Sulgi]Cho, J.Y.[Cho, Jae Youl]Kim, K.-S.[Kim, Kyung-su]Song, C.[Song, Changsik]Premkumar, T.[Premkumar, Thathan]
Issue Date
31-Dec-2023
Publisher
Elsevier B.V.
Keywords
Anticancer activity; Catalytic activity; Dextran; Green synthesis; Metal nanoparticles; Solid-state vibration ball milling
Citation
International Journal of Biological Macromolecules, v.253
Indexed
SCIE
SCOPUS
Journal Title
International Journal of Biological Macromolecules
Volume
253
URI
https://scholarx.skku.edu/handle/2021.sw.skku/108689
DOI
10.1016/j.ijbiomac.2023.127069
ISSN
0141-8130
Abstract
We propose a general green method coupled with a solid-state vibration ball milling strategy for the synthesis of various metal nanoparticles (MNPs), employing a polymeric carbohydrate dextran (Dx) as a reducing and stabilizing molecule. The synthesis of size-controlled Dx-based MNPs (Dx@MNPs), featuring comparatively narrow size distributions, was achieved by controlling the mass ratio of the reactants, reaction time, frequency of the vibration ball mill, and molecular weight of Dx. Notably, this process was conducted at ambient temperatures, without the aid of solvents and accelerating agents, such as NaOH, and conventional reductants as well as stabilizers. Thermal properties of the resulting Dx@MNPs nanocomposites were extensively investigated, highlighting the influence of metal precursors and reaction conditions. Furthermore, the catalytic activity of synthesized nanocomposites was evaluated through the reduction reaction of 4-nitrophenol, exhibiting great catalytic performance. In addition, we demonstrated the excellent biocompatibility of the as-prepared Dx@MNPs toward human embryonic kidney (HEK-293) cells, revealing their potential for anticancer activities. This novel green method for synthesizing biocompatible MNPs with Dx expands the horizons of carbohydrate-based materials as well as MNP nanocomposites for large-scale synthesis and controlled size distribution for various industrial and biomedical applications. © 2023 Elsevier B.V.
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