Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort studyopen access

Authors
Shin, EunhaeChi, Sang AhChung, Tae-YoungKim, Hee JinKim, KyungaLim, Dong Hui
Issue Date
Dec-2024
Publisher
BioMed Central Ltd
Keywords
Dementia; Herpes simplex virus (HSV); Subtype; Varicella zoster virus (VZV)
Citation
Alzheimer's Research and Therapy, v.16, no.1
Indexed
SCIE
SCOPUS
Journal Title
Alzheimer's Research and Therapy
Volume
16
Number
1
URI
https://scholarx.skku.edu/handle/2021.sw.skku/110556
DOI
10.1186/s13195-024-01418-7
ISSN
1758-9193
1758-9193
Abstract
Background: In this study, the risk of dementia in patients with a history of herpes simplex virus (HSV) or varicella zoster virus (VZV) infection was evaluated. Methods: This nationwide cohort study used data from the Korean National Health Insurance Service collected between 2006 and 2017. A total of 752,205 subjects ≥ 45 years of age not diagnosed with dementia until 2006 were included. A multivariate Cox regression model, adjusted for age, sex, and other comorbidities, was used to assess the hazard ratio (HR) for dementia based on VZV or HSV infection. The interaction effects of both viral infections were analysed. Viral infections are classified into four categories: eye, central nervous system (CNS), simple, and complicated. The hazard ratio (HR) of viral infection was analysed based on the type of dementia. Results: In multivariable analysis, both HSV and VZV infection were associated with an increased risk of dementia (HR = 1.38, 95% confidence interval, CI:1.33–1.43) and (HR = 1.41, 95% CI:1.37–1.46), respectively. Patients who experienced both HSV and VZV infections were also at an increased risk of dementia (HR = 1.57, 95% CI:1.50–1.63). The co-infection group showed the shortest time from viral infection to dementia diagnosis (4.09 ± 3.02 years). In the subgroup analysis, all types of HSV and VZV infections were associated with an increased risk of dementia compared to the non-infection group. The eye, CNS, and complicated VZV infections were associated with a significantly higher risk than simple VZV infections. There were no significant differences between the subtypes of HSV infection. Furthermore, HSV, VSV, and co-infection were associated with an increased risk of all dementia types, including Alzheimer’s disease (AD) and vascular dementia (VD). Conclusions: Individual HSV and VZV infections were associated with an increased risk of all types of dementia, including AD and VD. Patients co-infected with HSV and VZV, VZV infection in the eye, CNS, or complicated type were more vulnerable to the development of dementia. © The Author(s) 2024.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Medicine > Department of Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher LIM, DONG HUI photo

LIM, DONG HUI
Medicine (Medicine)
Read more

Altmetrics

Total Views & Downloads

BROWSE