A new approach to non-enzymatic glucose sensing with real blood sample analysis: Utilizing nickel-cobalt tungstate

초록

Undertaking the exploration of a natural non-enzymatic electrode catalyst to achieve highly sensitive and selective molecular detection, especially for targeting biomolecules, posed a significant and challenging endeavour. Metal oxides have garnered considerable interest as promising electrodes for glucose-sensing applications. In this study, we reported the successful synthesis of bimetallic Ni-Co tungstate (NCW) thin film electrodes on a stainless steel (SS) substrate using the cost-effective successive ionic layer adsorption and reaction (SILAR) method. The SILAR method provides the advantage of creating a porous, nanocrystalline, self-supported thin layer of Ni-Co tungstate on an SS substrate. Elemental composition analyses using EDS reveal that the thin films are formed with the desired Ni to Co ratio with spherical nanoparticle-like morphology. The film with a Ni:Co ratio 1:3 (NCW-4) shows a broad linear detection range (0.05 mM to 0.9 mM of glucose concentration), high sensitivity (18100 µA mM−1 cm−2), and a low limit of detection (0.0073 mM). Due to these qualities, NCW-4 films are further employed for real blood non-enzymatic glucose sensing applications. The accuracy rate for blood samples found in range between 95 % and 99 % compared to commercially available glucometer, confirming their practical usability and encourages their prospective application in the creation of other devices. © 2024 Elsevier B.V.

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