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Cardiovascular safety profile of JAK inhibitors and ethnic factors in Asians: A signal detection study using the Global ICSR (WHO-UMC VigBase) database
- Nam, Woongshik;
- Bae, Ji-Hwan;
- Oh, Jeongin;
- Shin, Ju-Young;
- Kim, Hoon
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0초록
Objective: This study aimed to detect cardiovascular disease-related signals using Global Individual Case Safety Report data on JAK inhibitors. Materials and methods: A signal detection study was conducted using the WHO-UMC VigiBase. Results: This study identified four cardiovascular adverse event signals associated with JAK inhibitors in Asian populations, including pulmonary embolism, deep vein thrombosis, thrombosis, and cerebrovascular accidents. Conclusion: Analysis of Asian populations revealed a higher risk ofthrom- boembolic events associated with JAK inhibitors than with TNF inhibitors. However, unlike in the Western populations, no myocardial infarction signal was detected in the Asian populations.
키워드
JAK inhibitors; TNF inhibitors; cardiovascular desease; signal detection; RISK
- 제목
- Cardiovascular safety profile of JAK inhibitors and ethnic factors in Asians: A signal detection study using the Global ICSR (WHO-UMC VigBase) database
- 저자
- Nam, Woongshik; Bae, Ji-Hwan; Oh, Jeongin; Shin, Ju-Young; Kim, Hoon
- DOI
- 10.5414/CP204580
- 발행일
- 2025-04
- 유형
- Article; Early Access
- 권
- 63
- 호
- 4
- 페이지
- 160 ~ 163