Recent strategies for designing adhesive hydrogels to enhance muscle tissue regeneration (NOV, 10.1007/s13534-025-00540-1, 2026)
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In this article, the captions for Figures 5 and 6 were inadvertently omitted. The correct captions are given below. Fig. 5 Pre-formed tissue-adhesive hydrogel interfaces for muscle repair. (a) SSGAE: sticky, strain-gradient artificial epineurium with an instant wet-adhesive layer and two hydrophobic elastomer layers that redistribute strain, enabling sutureless repair and drug-reservoir functionality from rodents to non-human primates. (b) TA-SA-PNI: laser-patterned Cu/Au serpentine embedded in a self-healing polymer with a phenylboronic-acid alginate primer, providing stiffness-adaptive, suture-free, stable bidirectional interfacing on sciatic nerve under large strain. (c) CA-HE film electroceutical: Janus alginate (adhesive AlBA layered with elastic AlMA) supporting soft PEDOT:PSS electrodes; the thin, gradient cuff self-locks on small-diameter nerves and lowers stimulation thresholds. (d) Adhesive nerve bandage (ANB/ACNB): polypyrrole-doped hydrogel fibers wrap and adhere to wet sciatic nerve without sutures, preserving conformal contact during motion. Fig. 6 Schematic of an injectable, wet-adhesive conductive hydrogel delivered into a muscle defect to provide immediate low-impedance coupling (lightning icon) and conformal sealing. The outer ring summarizes the design logic: (i) address mechanical mismatch and durable wet adhesion on contracting tissue; (ii) enable minimally invasive deployment with on-demand top-ups of cells/drugs; (iii) support closed-loop therapy (stimulation/recording) for force recovery; and (iv) incorporate bioactive release (growth factors/anti-oxidants) to steer regeneration. Co-designed adhesion with conduction via phenolic/quinone, boronate or dynamic-imine bonding integrated with soft-electronic phases (e.g., conducting polymers, MXenes, carbons) maintains contact through strain and motion, limiting impedance drift. Looking forward, temporal adaptivity is emphasized: high initial fixation to prevent washout, followed by controlled relaxation as tissue heals, yielding suture-free interfaces that seal, sense, and stimulate from placement through recovery. The original article has been corrected.

제목
Recent strategies for designing adhesive hydrogels to enhance muscle tissue regeneration (NOV, 10.1007/s13534-025-00540-1, 2026)
저자
Lee, YesungPark, YoubinShin, Mikyung
DOI
10.1007/s13534-026-00558-z
발행일
2026-02
유형
Correction; Early Access
저널명
Biomedical Engineering Letters (BMEL)
16
2
페이지
573 ~ 573