상세 보기
초록
Epithelial cell death driven by oxidative stress is a hallmark of inflammatory bowel disease (IBD), but the upstream triggers are unclear. A new study reveals that fibroblast-derived lipids enriched with polyunsaturated fatty acids induce epithelial ferroptosis. Genetic or pharmacological inhibition of fibroblast ACSL4 alleviates intestinal inflammation and injury in IBD models. © Springer Nature Limited 2025.
키워드
FERROPTOSIS
- 제목
- When gut fibroblasts feed epithelial cells to death
- 저자
- Kim, Jong Woo; Jeong, Byeong Jun; Lee, Eun-Woo
- 발행일
- 2025-06
- 유형
- Editorial Material; Early Access
- 저널명
- NATURE METABOLISM
- 권
- 7
- 호
- 7
- 페이지
- 1307 ~ 1309