ScholarWorks@성균관대학교

초록

This work discloses the first enantioselective copper-catalyzed acylation of 1,3-enynes with acyl fluorides. The reaction proceeds via an enantioenriched allenylcopper species that is chemoselectively generated from enynes in the presence of competing acyl fluorides. The resulting products bearing all-carbon quaternary centers are obtained with high enantioselectivity through a copper-oxygen-coordinated transition state. The method provides a practical and scalable strategy for asymmetric C-C bond formation with broad functional group tolerance.

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