ScholarWorks@성균관대학교

초록

Achieving effective and patient-specific bone regeneration is challenging because of structural, mechanical, and biochemical mismatches of the implant with defect. Here, we developed a portable device for the in situ fabrication of bone implants composed of polycaprolactone (PCL) and hydroxyapatite (HA). The low-melting-point extrusion method allowed direct printing and shaping of construct on defects without prefabrication or tissue damage. By adjusting HA content and the molecular weight of PCL, we optimized the mechanical and biological properties of the scaffolds for structural stability, long-term performance, and osteoconductivity. Incorporation of antibiotics in the system can prepare in situ implants with reduced infection risk. The in situ printing platform was assessed in a critical-sized bone-defect animal model and demonstrated therapeutic potential with robust new bone formation.

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