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초록

Fumonisin B1 (FB1) poses significant health risks to humans, yet existing detection methods generally suffer from limited approaches and insufficient accuracy. Consequently, establishing a multimodal detection strategy has become an effective pathway to enhance detection performance. This study developed a dual-mode sensing platform integrating photoelectrochemical (PEC) and colorimetric (CL) detection based on a heterojunction Bi2S3- x @CoSnO3@CoO with MnO2 nanoflower material exhibiting oxidase-mimetic activity. Within this platform, the dual-type II heterojunction with a stepwise electron transfer pathway synergistically interacts with MnO2-functioning as a p-DNA marker-significantly enhancing photocurrent response. Simultaneously, manganese dioxide catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to produce oxidized TMB (oxTMB), resulting in a distinct color gradient in the solution corresponding to different concentrations of FB1. Experimental results demonstrate that the sensor exhibits a broad linear detection range from 100 fg/mL to 100 ng/mL in PEC mode, with a detection limit as low as 41.6 fg/mL. In CL mode, the detection range spans 50 fg/mL to 10 ng/mL, achieving a detection limit of 24.6 fg/mL. This dual-mode sensing strategy not only enhances detection reliability and applicability but also provides novel insights and methodologies for novel sensor design.

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