Risk of Parkinson's Disease among Breast Cancer Survivors: A Nationwide Cohort Study in South Korea

초록

Background: Parkinson's disease (PD) and breast cancer are both significant public health concerns, but limited studies have explored a potential link between them. This study aims to investigate the risk of PD among breast cancer survivors in South Korea.Methods: Data from the Korean National Health Insurance Service (2010-2016) were used to identify 71,924 breast cancer survivors, matched 1:3 to 122,331 women without cancer. Subdistribution HRs (sHR) for PD were calculated using competing risk models adjusted for sociodemographic factors and comorbidities. Lag analysis at 1, 3, and 5 years after diagnosis assessed PD risk beyond these time points.Results: Over a mean follow-up of 7.1 years, 179 breast cancer survivors developed PD. Overall, there was no significant increase in PD risk compared with the general population [sHR, 0.91; 95% confidence interval (CI), 0.76-1.10]. However, younger survivors (age <= 50) showed a trend toward increased PD risk over time (sHR, 1.09; 95% CI, 0.58-2.05 at the 1-year lag period; sHR, 1.28; 95% CI, 0.64-2.58 at the 3-year lag period; and sHR, 1.49; 95% CI, 0.63-3.51 at the 5-year lag period). Treatment with chemotherapy, endocrine therapy, or radiotherapy was not associated with increased PD risk.Conclusions: Breast cancer survivors did not exhibit a significantly increased risk of PD overall. However, younger survivors showed a possible age-related elevation in risk over time.Impact: This is the first nationwide study to evaluate PD risk among breast cancer survivors. Findings suggest the need for further investigation into age-specific neurodegenerative risks in breast cancer survivorship.

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