Factors associated with cognitive reserve according to education level
  • Kim, Yeshin
  • Stern, Yaakov
  • Seo, Sang Won
  • Na, Duk L.
  • Jang, Jae-Won
  • 외 1명
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초록

INTRODUCTION: We investigated distinctive factors associated with cognitive reserve (CR) based on education level. METHODS: Among 1247 participants who underwent neuropsychological assessment, amyloid positron emission tomography, and brain magnetic resonance imaging, 336 participants with low education (<= 6 years) and 697 with high education (>= 12 years) were selected. CR was measured as the difference between the predicted and observed value of cognitive function based on cortical thickness. Multiple linear regression was conducted in each group after controlling for age and sex. RESULTS: In the low-education group, low literacy, long sleep duration(>8 h/day), and diabetes were negatively associated with CR, whereas cognitive and physical activity were positively associated with CR. In the high-education group, cognitive activity was positively related to CR, whereas low literacy, long sleep duration (> 8 h/day), and depression were negatively related to CR. DISCUSSION: This study provides insights into different strategies for enhancing CR based on educational background.

키워드

Alzheimer's diseasecognitive reserveeducationrisk factorsALZHEIMERS-DISEASEDIABETES-MELLITUSDIAGNOSTIC GUIDELINESNATIONAL INSTITUTERISKDEMENTIAIMPAIRMENTDECLINEBRAINRECOMMENDATIONS
제목
Factors associated with cognitive reserve according to education level
저자
Kim, YeshinStern, YaakovSeo, Sang WonNa, Duk L.Jang, Jae-WonJang, Hyemin
DOI
10.1002/alz.14236
발행일
2024-11
유형
Article; Early Access
저널명
Alzheimer's and Dementia
20
11
페이지
7686 ~ 7697