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초록
FLT3 mutations drive acute myeloid leukemia (AML) progression through aberrant signaling, making FLT3 inhibition a key therapeutic strategy. Current inhibitors show efficacy, yet resistance and toxicity remain challenges. Emerging approaches, including selective inhibitors, proteolysis-targeting chimeras, and protein degraders, offer enhanced potency, sustained suppression, and combinatorial potential, representing a precision-based advancement in AML treatment.
키워드
acute myeloid leukemia; antibody-drug conjugates; drug resistance; FLT3 inhibitors
- 제목
- Evolving paradigms in targeting FLT3 for acute myeloid leukemia therapy
- 저자
- Thapa, Rajan; Shrestha, Jesus; Paudel, Keshav Raj
- 발행일
- 2026-03
- 유형
- Editorial Material
- 권
- 47
- 호
- 3
- 페이지
- 244 ~ 247