ScholarWorks@성균관대학교

초록

Rationale and Objectives: This study evaluated glymphatic function changes according to MRI scan time over a 24-hour cycle, using diffusion tensor image analysis along the perivascular space (DTI-ALPS) to assess interstitial fluid dynamics. Material and Methods: This single-center retrospective cohort study included cognitively normal participants between January and August 2023. Participants were grouped by MRI scan time: dawn, early morning, daytime, and evening/night. Glymphatic function was assessed via the ALPS index calculated from DTI. ALPS index values were compared among groups using one-way ANOVA with post hoc pairwise independent t-tests. Multiple linear regression analysis adjusted for age, sex, and mini-mental state examination scores was used to compare daytime ALPS index with other groups. Paired t-tests assessed ALPS index changes in participants with follow-up MRIs. Results: Among 539 participants (age: 70 +/- 10 years, 41.4% male), the dawn group had the highest mean ALPS index, followed by early morning, evening/night, and daytime groups (P =0.024). Daytime ALPS index was significantly lower than dawn (P =0.0036) and early morning (P =0.018). Multiple linear regression confirmed lower daytime ALPS index, with the dawn group showing the largest difference (0.067, 95% CI: 0.025-0.108; P =0.002). No significant difference was observed in ALPS index for follow-up scans from dawn or evening/night to daytime (P =0.353). Conclusion: Glymphatic function varies diurnally, with lower values during daytime. These findings emphasize the importance of circadian timing in evaluating glymphatic function using DTI-ALPS. Further studies are needed to explore intra-individual glymphatic variations.

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