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Recent advances in organocatalytic enantioselective syntheses of β-fluoroamine compounds
- Do, Taeyang;
- Kim, Geun Ho;
- Rios, Ramon;
- Yang, Jung Woon
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1초록
beta-Fluoroamines are valuable entities in pharmaceutical, medicinal chemistry, and biochemistry. This review highlights the recent advances in transition metal-free and organocatalytic methods for the regio- and stereo- selective synthesis of chiral 1,2-aminofluorinated alkyl compounds. Synthetic methods for direct 1,2- and 1,4aminofluorination, along with fluorocyclization reactions, are described an enantioselective manner, with a focus on organocatalytic reactions involving a Lewis base, phase-transfer, and hypervalent iodine catalysis. The results of a comprehensive mechanistic study of each reaction are presented, along with a detailed perspective.
키워드
Enantioselective fluorination; beta-fluoroamines; Organocatalysis; Phase-transfer catalysis; Hypervalent iodine chemistry; NUCLEOPHILIC FLUORINATION; ASYMMETRIC FLUORINATION; ORGANIC CATALYSIS; HYDROGEN-FLUORIDE; METAL-FREE; ACID; CHEMISTRY; BOND; ALKENES; (DIACETOXYIODO)ARENES
- 제목
- Recent advances in organocatalytic enantioselective syntheses of β-fluoroamine compounds
- 저자
- Do, Taeyang; Kim, Geun Ho; Rios, Ramon; Yang, Jung Woon
- 발행일
- 2025-04
- 유형
- Review
- 저널명
- MOLECULAR CATALYSIS
- 권
- 576