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HFIP-Promoted PdH-Electrocatalytic Remote Ritter-Type Hydrofunctionalization of Alkenes: Divergent Access to Amides and Tetrazoles
- Park, Seungdae;
- Kim, Taehwan;
- Choi, Junhyeon;
- Ryu, Do Hyun;
- Shin, Kwangmin
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0초록
Ritter-type hydrofunctionalization of alkenes provides an efficient approach for constructing C(sp3)-N bonds, but it is generally limited to amide installation at original alkene position. Herein, we report an electrooxidative palladium-hydride-catalyzed remote and divergent Ritter-type hydrofunctionalization of alkenes. In this catalytic system, a nitrilium intermediate generated at a distal position is intercepted by HFIP to furnish a HFIP-derived imidate, which serves as a branching intermediate for telescoped remote hydroamidation and hydrotetrazolation. Mechanistic studies elucidate that HFIP facilitates palladium-hydride formation, and further reveal the role of electrooxidation in governing product formation.
키워드
C-H AMINATION; WALKING
- 제목
- HFIP-Promoted PdH-Electrocatalytic Remote Ritter-Type Hydrofunctionalization of Alkenes: Divergent Access to Amides and Tetrazoles
- 저자
- Park, Seungdae; Kim, Taehwan; Choi, Junhyeon; Ryu, Do Hyun; Shin, Kwangmin
- 발행일
- 2026-05-01
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 28
- 호
- 17
- 페이지
- 5580 ~ 5585