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AbClick Pro H: Scavenger-Free, Traceless Lys248 Conjugation Via O-Acyl Hydroxamate Chemistry for Homogeneous Antibody-Drug Conjugates (ADCs)
- Son, Jinyoung;
- Seo, Jin Woo;
- Park, Sun Hee;
- Yeom, Hojin;
- Ko, Nayoung;
- ... Chung, Sang J.;
- 외 5명
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0초록
A traceless O-acyl hydroxamate Fc-binding peptide linker enables rapid, scavenger-free, and site-selective conjugation at Lys248 of human IgG1. The resulting homogeneous DAR2 antibody-drug conjugates (ADCs) retain antigen binding and internalization with payload-dependent stability and cytotoxicity. The linker's intrinsic leaving-group mechanism ensures clean FcBP release and broad payload compatibility. This robust, scalable traceless Lys248 conjugation chemistry underpins investigational new drug (IND)-approved and nonclinical ADC pipelines, offering a predictable platform for next-generation ADC design.
키워드
STABILITY; VEDOTIN
- 제목
- AbClick Pro H: Scavenger-Free, Traceless Lys248 Conjugation Via O-Acyl Hydroxamate Chemistry for Homogeneous Antibody-Drug Conjugates (ADCs)
- 저자
- Son, Jinyoung; Seo, Jin Woo; Park, Sun Hee; Yeom, Hojin; Ko, Nayoung; Lee, Young Geun; Kim, Jinyoung; Kim, Ju Hwan; Park, Seong-Hyun; Han, Taedong; Chung, Sang J.
- 발행일
- 2026-01-16
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 28
- 호
- 2
- 페이지
- 764 ~ 767