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초록
Indocyanine green (ICG), the only FDA-approved near-infrared (NIR) dye, is widely used in bioimaging but suffers from rapid photobleaching and nonspecific biodistribution. Here we introduce KR-NIR-P, a polymerized form of ICG that preserves its NIR fluorescence while markedly enhancing stability. Under continuous illumination, KR-NIR-P retained similar to 66% of its initial fluorescence at 200 s, compared to similar to 40% for free ICG within the first 50 s. The polymer was efficiently internalized into immortalized cancer cells (HeLa, HSC-3) and primary human dermal fibroblasts (HDFs), exhibiting predominant cytosolic localization with >90% cell viability even at 20 & micro;M, confirming excellent biocompatibility. The inclusion of both immortalized and primary cells underscores the polymer's broad compatibility across physiologically diverse models. This straightforward polymerization strategy provides a robust and durable NIR imaging platform, overcoming the key drawbacks of ICG and broadening its utility for advanced biomedical research and clinical translation.
키워드
- 제목
- Indocyanine Green-Inspired Polymeric Chromophores With Intrinsic Photostability for Near-Infrared Imaging
- 저자
- Lee, Su Bin; Choi, Minsuk; Son, Young Hoon; Kim, Minseo; Park, Hye Sun; Kim, Seung Hyeon; Juraev, Ogabek Oybek Ugli; Jung, Hyocheol; Bae, Hyoung Eun; Jeong, Ji‐Eun; Jin, Young‐Jae; Kim, Jin Chul; Park, Sung‐Jin; Nam, Sang Hwan; Park, Young Il
- 발행일
- 2026-04-15
- 유형
- Article; Early Access
- 저널명
- Small