ScholarWorks@성균관대학교

초록

Background Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is well-established for lung cancer diagnosis and staging, evidence in older patients remains limited. This study compared the diagnostic value and safety between older and younger groups.<br /> Methods For this systematic review and meta-analysis, we conducted a comprehensive search across databases, including PubMed, Embase, and the Cochrane Central Register. Older patients were defined as >= 65 or >= 70 years, according to study-specific criteria, and younger patients as below these thresholds. A proportional meta-analysis was performed to estimate the pooled diagnostic yield of the EBUS-TBNA.<br /> Results We found six studies comprising 5,206 participants. The pooled diagnostic yield for overall diagnosis was similar between the older and younger patients (0.96 vs. 0.97; P = 0.81 ) The pooled diagnostic yield for malignancy detection was higher in the older patients than in the younger patients (0.59 vs. 0.51; P < 0.01 ) There was no significant difference in the overall complication rate between the two groups (risk ratio, 0.95; 95% confidence interval [C], 0.74 1.23). The older group received a significantly lower average dose of midazolam compared to the younger group (mean difference [MD], -1.11 mg; 95% CI,1.58 to 0.63; P < 0.01 ) The duration of the procedure was comparable between the two groups (MD, -0.03 min; 95% CI, -1.44 1.38; P = 0.97 )<br /> Conclusions Our findings suggest that EBUS-TBNA can be safely and effectively performed in older patients, with diagnostic outcomes comparable to those in younger individuals.

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