상세 보기
- Jung, Jin Young;
- Ahn, Yeeun;
- Park, Jung-Wook;
- Jung, Kyeongmin;
- Kim, Soyeon;
- ... Park, Woong-Yang;
- ... Won, Hong-Hee;
- 외 10명
WEB OF SCIENCE
3SCOPUS
2초록
Subjective well-being (SWB) is important for understanding human behaviour and health. Although the connection between SWB and psychiatric disorders has been studied, common genetic mechanisms remain unclear. This study aimed to explore the genetic relationship between SWB and psychiatric disorders. Bivariate causal mixture modelling (MiXeR), polygenic risk score (PRS) and Mendelian randomization (MR) analyses showed substantial polygenic overlap and associations between SWB and the psychiatric disorders. Subsequent replication studies in East Asian populations confirmed the polygenic overlap between schizophrenia and SWB. The conditional and conjunctional false discovery rate analyses identified additional or shared genetic loci associated with SWB or psychiatric disorders. Functional annotation revealed enrichment of specific brain tissues and genes associated with SWB. The identified genetic loci showed cross-ancestry transferability between the European and Korean populations. Our findings provide valuable insights into the common genetic mechanisms underlying SWB and psychiatric disorders. © The Author(s), under exclusive licence to Springer Nature Limited 2025.
키워드
- 제목
- Polygenic overlap between subjective well-being and psychiatric disorders and cross-ancestry validation
- 저자
- Jung, Jin Young; Ahn, Yeeun; Park, Jung-Wook; Jung, Kyeongmin; Kim, Soyeon; Lim, Soohyun; Jung, Sang-Hyuk; Kim, Hyejin; Kim, Beomsu; Hwang, Mi Yeong; Kim, Young Jin; Park, Woong-Yang; Okbay, Aysu; O’Connell, Kevin S.; Andreassen, Ole A.; Myung, Woojae; Won, Hong-Hee
- 발행일
- 2025-04
- 유형
- Article; Early Access
- 저널명
- Nature Human Behaviour
- 권
- 9
- 호
- 6
- 페이지
- 1272 ~ 1282