Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD
  • Kwon, Young Nam
  • Tisavipat, Nanthaya
  • Guo, Yong
  • Syc-Mazurek, Stephanie B.
  • Han, Ji Yeon
  • ... Kim, Byoung Joon
  • 외 19명
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초록

Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) co-occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of MOGAD onset, resulting in a standardized incidence ratio for neoplasm of 3.10 (95% confidence interval [CI], 1.77–4.81; P < 0.001) when compared to the age- and country-adjusted incidence of neoplasm in the general population. However, none of the nine tumor tissues obtained demonstrated MOG immunostaining. The slightly increased frequency without immunohistopathological evidence suggest with true paraneoplastic MOGAD is extremely rare. © 2025 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

제목
Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD
저자
Kwon, Young NamTisavipat, NanthayaGuo, YongSyc-Mazurek, Stephanie B.Han, Ji YeonKim, Jun-SoonChoi, KyominOh, Seong-ilChoi, Seok-JinSohn, EunheeOh, JeeyoungKim, Seung WooShin, Ha YoungLim, Byung ChanKim, Byoung JoonPark, Kyung SeokSung, Jung-JoonKim, Se HoonPark, Sung-HyeZekeridou, AnastasiaLucchinetti, Claudia F.Pittock, Sean J.Chen, John J.Flanagan, Eoin P.Kim, Sung-Min
DOI
10.1002/acn3.52301
발행일
2025-02
유형
Article; Early Access
저널명
Annals of Clinical and Translational Neurology
12
4
페이지
861 ~ 870